ACX Grants 2025 | Manifund

This is a collection of grants selected by Scott Alexander of ACX, and made through Manifund. See also: https://www.astralcodexten.com/p/apply-for-an-acx-grant-2025

What is ACX Grants?

ACX Grants is a microgrants program that helps fund ACX readers’ charitable or scientific projects. Click the links to see the 2022 and 2024 cohorts.

The program is conducted in partnership with Manifund, a charity spinoff of Manifold Markets, who handle the administrative/infrastructure side of things.

What kind of projects might you fund?

There are already lots of good charities that help people directly at scale, for example Against Malaria Foundation (which distributes malaria-preventing bed nets) and GiveDirectly (which gives money directly to very poor people in Africa). These are hard to beat.

We’re most interested in charities that pursue novel ways to change complex systems, either through technological breakthroughs, new social institutions, or targeted political change. Among the projects we’ve funded in the past were:

Development of oxfendazole, a drug for treating parasitic worms in developing countries.
A platform that lets people create prediction markets on topics of their choice
A trip to Nigeria for college students researching lead poisoning prevention.
A group of lawyers who sue factory farms under animal cruelty laws.
Development of software that helps the FDA run better drug trials.
A startup building anti-mosquito drones to fight tropical disease
A guide for would-be parents on which IVF clinics have the highest successful rate of successful implantation.
A university lab working on artificial kidneys

You can read the full list here and here, and the most recent updates from each project here.