make and sell far-UVC lamps for air disinfection

Make cheap, inherently safe, and effective consumer 222nm far-UVC lamps for air and surface disinfection

Research introduction of new antibiotics

Since new antibiotics are a rare and precious resource, how do we best introduce them to minimize the emergence and spread of resistance?

AI that standardizes and curates bio datasets

Create a permanent, public, and computable foundation of biological knowledge by building an AI-powered engine that automatically standardizes and curates the world’s biological datasets—past, present, and future.

Eradicate the hidden factory farming of feeder rodents

Developing and commercializing an alternative to feeder rodents—tackling one of the most neglected and high-suffering forms of factory farming.

Transformative AI scenarios for EU policymakers

Build awareness and urgency among European policymakers on AI’s rapid, transformative impacts through future scenarios and targeted institutional engagement

Building Effective Giving ecosystem in India

Funding circles and advisory to fund high impact non-profits

Improve eligibility for organ donation

Help previously ineligible living organ donors become eligible to donate

mRNA for airway disease

Cure idiopathic pulmonary fibrosis, eventually reverse lung aging

Search for more solar system objects

Purchase compute and support algorithm development

Lead-acid battery recycling in Philippines

Develop and promote market-based policies to reduce informal lead-acid battery recycling in the Philippines.

Vaccine manufacturing platform

Creating a manufacturing platform to rapidly and scalably manufacture vaccines against current and emerging viral pandemic threats.

YIMBY movement for African cities

Support the AUL to bring a YIMBY movement to African cities so these cities can build the urban infrastructure needed to accommodate ~900 million new urbanites by 2050.

Charting the Policy Landscape of Advanced Education in America

This nationwide report will provide a detailed account of the policies states have that in place to help advanced learners thrive.

OpenReg: AI tools for FDA application and reg compliance

A set of AI-powered open-source tools intended to shorten time-to-market for medtech innovators.

Human Inductive Bias Project

Investigating intersection between mathematical models of human and machine learning

Disentangling Political Bias from Epistemic Integrity in AI Systems

An Integrative Framework for Auditing Political Preferences and Truth-Seeking in AI Systems

Advertise Christians for Impact (EA for Christians)

Scale the reach of evidence-based, impact-focused career advice for Christians through a high-leverage digital engagement campaign at Christians for Impact.

Is electrical stunning a humane slaughter method for decapods?

Produce a peer-reviewed literature review assessing whether electrical stunning is a humane method for slaughtering decapod crustaceans, identifying evidence gaps, methodological flaws, and next research steps to guide advocacy and policy.

Good Ancestors (Australia)

Advocate for Australian policies that safeguard against global catastrophic risks – including pandemics, AI risks, and catastrophic disasters.

Scale up biologics manufacturing

Develop a system to enable scalable, cheap, yeast-based manufacturing of difficult biologics using a continuous in vivo evolution platform, facilitating cheaper medicines, new drugs, and broadening access in low-income countries by enabling manufacturing will less reliance on cold chains.

Produce therapeutic food for Ethiopia

Production and distribution of peanut butter based therapeutic food for the treatment of childhood malnutrition in northern Ethiopia

Automated forecasting

Automate Forecasting in Unfun Domains - by Exploring with Shapley Attribution and all the other Low Hanging Fruits.

"Sweeten" training corpora with stories of nice AI

Flood the internet with stories about AI being nice, to nudge future AI training data nicer

Train LLMs in honest introspection

Train LLMs to accurately & honestly report on their internal decision-making processes through real-time introspection

Screwworm Free Future: Seizing the Eradication Window

Accelerate eradication of the New World Screwworm from South America via research, coordination, and advocacy around safe development of gene-drives

AI-assisted low-cost ultrasound scanner

Low-cost wearable ultrasound scanner backed with AI diagnostics available to people at home or in settings where hospitals are inaccessible

Software to detect data fabrication

Continue developing ‘copy-paste-detective’ - a software that detects signs of data fabrication in scientific research - and run it against 20,000 publicly available Excel datasets.

Forecasting global disasters

Elite cyborg forecasters identify and share the most important signs of global catastrophic risks for you and the public.

HIV/TB clinic in Africa

We want to integrate our HIV/TB clinic with our medical clinic at our hospital in rural Kenya and tell the world about it to promote conversations about how to continue providing excellent outpatient HIV/TB care as foreign aid to support these projects changes.

Fish welfare training in Nigeria

Pilot a scalable, direct-to-farmer fish welfare program in Nigeria, training 400+ farmers across five clusters to adopt and maintain humane handling, slaughter, and welfare practices through hands-on field training and ongoing farm support.

Strengthening the biosecurity in Liberia (West Africa)

Development of Biosafety Laboratory Assessment Matrix (BLAM) for Liberia (West Africa)

Clean Indoor Air for Schools

Accelerating the adoption of air filters in every classroom

AI to screen DNA orders

Create open-source AI tools for customer screening of DNA orders.

Gene editing corn for nutrition

Use a new and more precise form of gene editing to increase the nutritional content of corn, primarily for Central America and Sub-Saharan Africa.

Native psilocybin use in Southern Africa

Continue documenting the indigenous use of native Psilocybe mushrooms in Lesotho, including the collection of physical samples, to identify novel medical applications of psilocybin.

Normie-friendly prediction market interfaces

Normie-friendly interfaces for prediction markets and their probabilities

The Metascience Observatory Replications Database

Using an AI-powered pipeline to study how often experiments replicate across fields, countries, and journals.

Offline AI voice restoration device for people with voice disorders

I am developing a portable, offline AI assistive medical device which restores disordered speech to a clear, natural voice.

More End Kidney Deaths campaigning

Continue leading a national campaign to pass the End Kidney Deaths Act (H.R. 2687), a bill projected to save 100,000 lives and $37B in taxpayer costs over the next decade.

Develop an app or website to help parents choose between IVF clinics

Improving fish welfare through producer and retail outreach in Türkiye

Seed fund for boundaries-based empirical AI safety projects after workshop.

Tardigrade stress tolerance genes that modified for improved performance in human cells.

Build a new nonprofit thinktank that advances technological solutions to animal welfare challenges

Create open source predictors for various genetically influenced traits such as intelligence and disease risk

Create a platform for assurance contracts that looks nice.

Validate a solution for ozone generation from far-UVC germicidal light

Replicate and extend brain entrainment results

Influenza Pandemic Protection on Day 1 through universal priming vaccines

Pivoting this project, due to stakeholder feedback. Former focus was inclusion of a pre-pandemic strain in a quadrivalent seasonal influenza vaccine

The first public benefit biotechnology company with an explicit goal of involuntary suffering abolition.

African School of Economics in Zanzibar charter city

Advocate for a specialized pandemic response team at the FDA

Promote Georgism

Scenario analysis and planning platform for more effective developing world agriculture projects

Study land reform

Direct land purchases and transfer from landowners to tenant farmers

Charge selective large pore membranes for artificial implantable kidney.

Build anti-mosquito drones

Assess online training platform for health workers in Nigeria

Combat global antibiotic resistance

Youtube tutorial videos about computational biology and bioinformatics

Use smartphone pupillometry to triage brain injury in rural Missouri.

Conduct field research on informal lead-acid battery recycling supply chains in Nigeria

An online platform to solve coordination problems and generate leverage through collective action campaigns

Develop an accessible, low-cost system for single-cell imaging in multiple regions of freely moving organisms

Write a good primer on political change.

Apart incubates and facilitates hundreds of AI safety researchers around the globe.

Advocate for policies that safeguard against global catastrophic risks

Pass laws to encourage living kidney donation

An organization for increased rights for minors, initially targeting the repeal of the Interstate Runaway Compact